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发布于:2018-12-6 22:29:23  访问:25 次 回复: 篇
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Tukey HSD (honestly significant difference) post hoc test and the Student
Both the number of injections and the type of treatment (either LTR-Ig or MOPC 21) played a role in determining the glucose levels, as shown by the significant Salvianolic acid BProtocol interaction effect (P < 0.001). The Kruskal-Wallis test and Dunn‘s multiple comparison test were used for the LTR-Ig level analysis using GraphPad version 4 (GraphPad Software, Inc., San Diego, CA, USA). P values of less than 0.05 were considered significant.ResultsEffect of LTR-Ig treatment on blood glucose levels As highlighted in the Introduction, several studies have reported successful prevention of diabetes development in NOD mice upon treatment with LTR-Ig. We used the blood glucose levels as an in-house control to determine the efficacy of LTR-Ig treatment. Both the number of injections and the type of treatment (either LTR-Ig or MOPC 21) played a role in determining the glucose levels, as shown by the significant interaction effect (P < 0.001). This finding was underscored by the low glucose levels at 16 weeks in the LT16 group compared with age-matched controls, and at 19 weeks, the LT19 group glucose levels were not only lower than those of the LT16 group, but also significantly different from those of agematched controls (Figure 1b).Tukey HSD (honestly significant difference) post hoc test and the Student t test. Two-way between-groups ANOVA was undertaken for specific comparisons of LTR-Ig and MOPC 21 treatment PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28607003 on blood glucose levels, inflammation, and saliva flow rates. The Mann-Whitney U test was used for non-parametric data. Pearson‘s correlation was used to describe linear relationships. Saliva cytokines were Z-standardized. SPSS version 15.0 (SPSS Inc., Chicago, IL, USA) was used for these analyses. The Kruskal-Wallis test and Dunn‘s multiple comparison test were used for the LTR-Ig level analysis using GraphPad version 4 (GraphPad Software, Inc., San Diego, CA, USA). P values of less than 0.05 were considered significant.ResultsEffect of LTR-Ig treatment on blood glucose levels As highlighted in the Introduction, several studies have reported successful prevention of diabetes development in NOD mice upon treatment with LTR-Ig. We used the blood glucose levels as an in-house control to determine the efficacy of LTR-Ig treatment. Both the number of injections and the type of treatment (either LTR-Ig or MOPC 21) played a role in determining the glucose levels, as shown by the significant interaction effect (P < 0.001). This finding was underscored by the low glucose levels at 16 weeks in the LT16 group compared with age-matched controls, and at 19 weeks, the LT19 group glucose levels were not only lower than those of the LT16 group, but also significantly different from those of agematched controls (Figure 1b). LTR-Ig treatment inhibits submandibular gland inflammation Submandibular salivary glands were examined for inflammation. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/27527552 The ratio index and focus score were used to determine the level of inflammation and the two methods showed a strong correlation (r = 0.807, n = 75, P < 0.001). LTR-Igtreated groups had reduced levels of inflammation as they aged and also the lowest inflammation levels compared with the controls at the different ages at which the mice were examined (Figure 1c, d).
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